IXplore IX85 Spin

Overview

	Quickly Capture Rapid Cell Dynamics The IXplore™ IX85-Spin system combines an advanced spinning disk unit and high-performance imaging tools to provide you with fast 3D confocal image acquisition and prolonged cell viability in timelapse experiments. Download the IX85 Brochure

Quickly Capture
Rapid Cell Dynamics

The IXplore™ IX85-Spin system combines an advanced spinning disk unit and high-performance imaging tools to provide you with fast 3D confocal image acquisition and prolonged cell viability in timelapse experiments.

Download the IX85 Brochure

Strikingly Clear Confocal Images

With a Yokogawa CSU-W1 spinning disk unit, the IXplore™ IX85-Spin system helps you acquire high-speed confocal images and conduct more efficient image stitching over a wide area. To help you see even more, TruSight deconvolution algorithms can be applied to improve image resolution, contrast, and dynamic range for strikingly clear 3D images, even at greater observation depths.

*Image: NIH 3T3 cells (Blue: Nuclei, Green: Tubulin, Magenta: Mitochondria, Gray: Fibrillarin)
Sample provided by EnCor Biotechnology Inc.

	Precise 3D Image Generation at Greater Depths The pinhole geometry of the IXplore™ IX85-Spin system’s Yokogawa spinning disk produces excellent image contrast at greater depths for imaging into thicker samples. Additionally, the IXplore™ IX85-Spin allows you to combine high-NA silicone oil objectives or our new groundbreaking silicone gel multi-immersion objective (LUPLAPO25XS) with a new auto correction collar to create exceptional light gathering and dimensional fidelity. These elements make the IXplore™ IX85-Spin your best choice for imaging live cells at high resolution without sacrificing speed, accuracy, or image quality. Our new LUPLAPO25XS introduces groundbreaking new silicone gel pad technology. See deeper into your samples and reveal structures that were previously out of reach with a high NA and long working distance. With this silicone gel pad objective, you can get the quality of silicone immersion with the useability of a dry objective. The new LUPLAPO25XS enhances workflows for organoids, 3D cell culture, well-plates, and a wide range of applications.
XYZ image comparison between Left: LUPLAPO25XS (Silicone gel) and Right: UPLXAPO20X (Dry) Cleared HeLa*1 cell spheroid (Cyan: Nuclei, Magenta: Microtubules) taken by IX85-Spin

Precise 3D Image Generation at Greater Depths

The pinhole geometry of the IXplore™ IX85-Spin system’s Yokogawa spinning disk produces excellent image contrast at greater depths for imaging into thicker samples. Additionally, the IXplore™ IX85-Spin allows you to combine high-NA silicone oil objectives or our new groundbreaking silicone gel multi-immersion objective (LUPLAPO25XS) with a new auto correction collar to create exceptional light gathering and dimensional fidelity. These elements make the IXplore™ IX85-Spin your best choice for imaging live cells at high resolution without sacrificing speed, accuracy, or image quality.

Our new LUPLAPO25XS introduces groundbreaking new silicone gel pad technology. See deeper into your samples and reveal structures that were previously out of reach with a high NA and long working distance. With this silicone gel pad objective, you can get the quality of silicone immersion with the useability of a dry objective. The new LUPLAPO25XS enhances workflows for organoids, 3D cell culture, well-plates, and a wide range of applications.

XYZ image comparison between Left: LUPLAPO25XS (Silicone gel) and Right: UPLXAPO20X (Dry)
Cleared HeLa*1 cell spheroid (Cyan: Nuclei, Magenta: Microtubules) taken by IX85-Spin

Simultaneous High-Speed Multichannel Imaging

The IXplore™ IX85-Spin laser combiner is scalable from two to six laser lines, and multi-camera configuration is available to support simultaneous multichannel imaging if you require higher speed or a wider information bandwidth. Excitation wavelengths include 405nm, 445nm, 488nm, 514nm, 561nm, and 640nm.

Cultured Cos 7 cell
Blue: Nuclear, Green: Mitochondria, Red: Tubulin, Magenta: Actin

IXplore™ IX85 Automated Inverted Microscope System

The foundation of our IXplore™ IX85-Spin system, the IXplore™ IX85 delivers the largest FOV in the industry and an array of advanced end-to-end imaging features, allowing you to see and capture more than ever before while dramatically reducing acquisition times. Experience exceptional speed, clarity, and reliability with the IXplore™ IX85 microscope system.

Learn more about the IXplore microscope system

See How Evident Microscopes with Spinning Disk Confocal Technology Have Been Used in Life Science Research

N. Elkhatib, et al. Tubular clathrin/AP-2 lattices pinch collagen fibers to support 3D cell migration. Science (June 16, 2017).

R. H. Herbst, et al. Heterosis as a consequence of regulatory incompatibility. BMC Biology (May 11, 2017).

N. Yanagisawa, et al. Capability of tip-growing plant cells to penetrate into extremely narrow gaps (May 3, 2017).

H. Cohen-Dvashi, et al. The role of LAMP1 binding and pH sensing by the spike complex of Lassa virus. Journal of Virology (September 7, 2016).

H. Ochiai, et al. Simultaneous live imaging of the transcription and nuclear position of specific genes. Nucleic Acids Research (June 19, 2016).

B. Guirao, et al. Unified quantitative characterization of epithelial tissue development. eLIFE (December 12, 2015).

I. Nemazanyy, et al. Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nature Communications (September 21, 2015).

K. Gooh, et al. Live-cell imaging and optical manipulation of arabidopsis early embryogenesis. Developmental Cell (July 9, 2015).

Y. Oda, et al. Rho of plant GTPase signaling regulates the behavior of arabidopsis kinesin-13A to establish secondary cell wall patterns. The Plant Cell (November 26, 2013).

*1 Although it became one of the most important cell lines in medical research, it’s imperative that we recognize Henrietta Lacks’ contribution to science happened without her consent. This injustice, while leading to key discoveries in immunology, infectious disease, and cancer, also raised important conversations about privacy, ethics, and consent in medicine.
To learn more about the life of Henrietta Lacks and her contribution to modern medicine, click here.
http://henriettalacksfoundation.org/