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Tissue Optical Clearing Imaging: From In Vitro to In Vivo 

Biomedical optical Imaging, as a powerful tool has been applied for observing biomedical tissue structural and functional information with high resolution and contrast unattainable by any other method. However, the high scattering of turbid biological tissues limits the penetration of light, leading to strongly decreased imaging resolution and contrast as light propagates deeper into the tissue. Fortunately, novel tissue optical clearing technique provide a way for reducing the scattering of tissue and improving the optical imaging quality. This presentation will introduce our progress from in vitro and in vivo of tissue optical clearing imaging, including developing in vitro optical clearing methods, such as FDISCO and MACS. Meanwhile, we will also demonstrate in vivo skull/skin optical clearing window for imaging structural and functional of cutaneous / cortical vascular and cells, also manipulating cortical vasculature.

Tissue Optical Clearing Imaging: From In Vitro to In Vivo

Biomedical optical Imaging, as a powerful tool has been applied for observing biomedical tissue structural and functional information with high resolution and contrast unattainable by any other method. However, the high scattering of turbid biological tissues limits the penetration of light, leading to strongly decreased imaging resolution and contrast as light propagates deeper into the tissue. Fortunately, novel tissue optical clearing technique provide a way for reducing the scattering of tissue and improving the optical imaging quality. This presentation will introduce our progress from in vitro and in vivo of tissue optical clearing imaging, including developing in vitro optical clearing methods, such as FDISCO and MACS. Meanwhile, we will also demonstrate in vivo skull/skin optical clearing window for imaging structural and functional of cutaneous / cortical vascular and cells, also manipulating cortical vasculature.

Especialistas
Dr. Dan Zhu
Professor
Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China

Dr. Dan Zhu is a professor of Huazhong University of Science & Technology, and Vice-Director of Wuhan National Laboratory for Optoelectronics. Her research interests mainly focus on tissue optical clearing imaging and applications. She is the pioneer in the field of in vivo tissue optical clearing, and also developed fast, label-compatible in vitro optical clearing methods. She has authored more than 150 papers including Science Advances, Nature Communications, et al. She is also Fellow of SPIE, and Secretary General & Vice President of Biomedical Photonics Committee of Chinese Optical Society. She serves for journals as editorial member or guest editor, including Biomedical Optics Express, Journal of Biomedical Optics, Scientific Reports, Journal of Innovative Optical Health Sciences, Frontier of Optoelectronics et al.

Tissue Optical Clearing Imaging: From In Vitro to In VivoNov 12 2024
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