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Overview
Transforming Precision ImagingIn-Depth Precision for In Vivo ExperimentsTransform your images with the FLUOVIEW™ FV4000MPE multiphoton laser scanning microscope. Advanced imaging technology reveals the details and dynamics of your samples while providing quantitative image data that can enhance your experiments. With our breakthrough SilVIR detector at the core of the system, achieve much lower noise, higher sensitivity, and improved photon resolving capabilities. Coupled with high speed to capture fast dynamics, the system empowers demanding research applications. |
Experience the system’s innovations, including:
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Multiphoton Imaging Made SimpleThe FV4000MPE microscope uses our advanced, silicon-based SilVIR™ detector that makes it easier than ever to acquire precise, reproducible data. SilVIR Next-Generation Detector Technology The SilVIR detector combines two advanced technologies—a silicon photomultiplier (SiPM) and our patented* fast signal processing design.
*Patent number US11237047 Learn more about the SilVIR detector | |
3D image of a live mouse brain from the surface to 900 µm deep using a TruResolution objective. The brighter neural cell body did not saturate thanks to the SilVIR detector’s high dynamic range.
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Outstanding Multiphoton Images at DepthThe FV4000MPE microscope equipped with a TruResolution objective can efficiently excite fluorochromes deep in your sample by concentrating excitation laser power to achieve a brighter image. The advanced nondescanned (NDD) SilVIR detector has a larger beam diameter to better collect scattered fluorescence emissions from deeper in samples. The upgraded non-descanned detector (NDD) can be configured for a maximum of six channels for multicolor multiphoton imaging. Resonant scanner enables you to acquire large-volume 3D images quickly. Stitched image of a cleared whole brain captured using 10X objective lens and resonant scanner (512x512 pixels. Z 501 slices, 225 positions). New resonant scanner has the ability to acquire equivalent quality images to galvo scanner in less than a third of the time.
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Gentler, High-Speed Time-Lapse Imaging
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Related VideosVisualization of glutamatergic synaptic inputs in vivo mouse FrA cortex using iGluSnFR.Courtesy of Katsuya Ozawa and Akiko Hayashi-Takagi, Multi-Scale Biological Psychiatry, RIKEN CBS. | Related VideosIn vivo Ca2+ imaging in mouse cortical neurons using jRGECO1a.Courtesy of Katsuya Ozawa and Akiko Hayashi-Takagi, Multi-Scale Biological Psychiatry, RIKEN CBS. |
Support and Service You Can Count OnThe FV4000MPE system is easy to maintain.
We stand behind our products with a commitment to fast service and technical support to help our customers achieve their goals. We offer various support plans to keep your microscope running at peak performance at a predictable cost as well as remote support options, so you don’t need to wait for an engineer or specialist to visit if you’re having an issue. |
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Configurations
Many Possibilities, One SystemDepending on your application, you can choose between upright, gantry, or inverted microscope frames. The FV4000MPE microscope is engineered to be modular, making it easy for you to configure the system based on your applications and budget. You can start with a standard FV4000MPE and easily upgrade to a combo system by adding the SPE module as your research changes. | ||
Upright Microscope System — For in vivo and in vitro multiphoton microscopy | Gantry Microscope System — For in vivo observations that require more space | Inverted Microscope System — For in vitro observation of 3D cell (spheroid) and tissue cultures |
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Specifications
Scanner | Galvanometer scanner (normal imaging) | 64 × 64–4096 x 4096 pixels, 1 μs/pixel–1000 μs/pixel | ||
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Resonant scanner (high-speed imaging) | 512 × 512 pixels, 1024 × 1024 pixels | |||
Field number (FN) | 20 | |||
Spectral confocal detector | Detector | SilVIR detector (cooled SiPM, broad band type/red-shifted type) | ||
Maximum channels | Six channels | |||
Spectral method | VPH, detectable wavelength range 400 nm–900 nm | |||
Non-descanned detector | Detector | SilVIR detector (cooled SiPM, broadband type/red-shifted type) | ||
Maximum channels | Six channels | |||
Laser | VIS laser | 405 nm, 445 nm, 488 nm, 514 nm, 561 nm, 594 nm, 640 nm | ||
NIR laser | 685 nm, 730 nm, 785 nm | |||
IR pulse laser |
One laser system, dual laser lines system, two lasers system
Excitation wavelength: 690 nm–1300 nm Four-axis auto alignment, auto beam expander | |||
Image | High dynamic range photon counting (1G cps) |