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Neuroscience

Life Science Research Application

Applications: Neuroscience Imaging

Neuroscience is the study of nerve function, structure, and development. Researchers need to observe single cells as well as the entire brain, on the surface and deep within the tissue. They also need to capture morphological changes and stimulus responses using living samples.

Olympus has a range of microscope solutions to meet the needs of neuroscience research. Our virtual slide scanner system offers the flexibility to view high-resolution digital imaging of the entire slide glass specimen at the same time as the magnified images. The FLUOVIEW confocal laser scanning microscopes enable continuous high-resolution multicolor fluorescence imaging and macro-to-micro observation through highly accurate image lamination. The spinning disk system is designed for live cell imaging with its confocal super resolution microscope, providing high-speed imaging with reduced phototoxicity. Our confocal microscopes capture the fine structure and morphological change of neurons and the deep structure of tissues with super resolution and clear three-dimensional images. They are also capable of capturing the high-speed responses of membrane potential and calcium sensitive dyes. Olympus also offers multiphoton laser scanning microscopes that can capture high-speed reactions and observe deep tissue.

Solutions for Neuroscience - Choose Your Configuration

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Microscope System/Frame

FV4000MPEShow Description
FV4000MPE

  • Acquire accurate, quantitative image data from the macro scale to subcellular structures
  • Obtain more information from a single multicolor image
  • Monitor neuron and other essential dynamics with high-speed imaging

FV4000MPE

Multiphoton Laser Scanning Microscope
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APX100Show Description
APX100

The APEXVIEW™ APX100 benchtop fluorescence microscope makes it fast and simple to acquire expert-quality microscope images. Built with our renowned optics, an intuitive user interface, a powerful AI, and a suite of smart features, the APX100 system combines ease of use with high-quality image data to fit your research needs.

  • Stay focused on your research
  • Save space—no darkroom required
  • Fast, efficient data management

APX100

Benchtop Fluorescence Microscope
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VS200Show Description
VS200
  • Outstanding image quality for whole slide imaging, from 2X to 100X, including oil scanning
  • Accommodates multiple slide sizes and observation methods
  • SILA optical sectioning device enables you to obtain high-contrast images free from blur across the entire slide
  • Simplified and powerful workflow, from brightfield to fluorescence multiplexing
  • Uniquely configurable software and hardware, from manual brightfield scanning to AI recognition and fully automated scanning

VS200

Research Slide Scanner
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IXplore SpinSRShow Description
IXplore SpinSR

The IXplore SpinSR system is our confocal super resolution microscope optimized for 3D imaging of live cell specimens. Like the IXplore Spin system, it has a spinning disk system for fast 3D imaging while limiting phototoxicity and bleaching. However, it achieves super resolution images down to 120 nm XY and enables you to switch between widefield, confocal, and super resolution with the click of a button.

  • Sharp, clear super resolution imaging down to 120 nm XY, owing to Olympus Super Resolution (OSR)
  • Prolonged cell viability in confocal time-lapse imaging due to less phototoxicity and bleaching
  • Use two cameras simultaneously to achieve fast, two-color super-resolution imaging
  • Super resolution imaging with the world’s first plan apochromat objectives with a numerical aperture (NA) of 1.5*
* As of November 2018. According to Olympus research.

IXplore SpinSR

Super Resolution Microscope System
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IXplore SpinShow Description
IXplore Spin

The IXplore Spin system features a spinning disk confocal unit that enables fast 3D image acquisition, a large field of view, and prolonged cell viability in time-lapse experiments. Researchers can use it to perform rapid 3D confocal imaging with high resolution and contrast at greater depths for imaging into thicker samples. The spinning disk also helps to cut down on photobleaching and phototoxicity of samples upon excitation.

  • Real-time controller (U-RTCE) helps optimize the device’s speed and precision during automated acquisition
  • TruFocus™ Z-drift compensation system maintains focus for each frame
  • Precise 3D imaging with improved light collection using X Line™ objectives
  • Upgrade to the IXplore SpinSR super resolution system as your research progresses

IXplore Spin

Confocal Imaging Microscope System
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BX51WIShow Description
BX51WI
  • Ideally suited to brain-slice and in-vivo electrophysiology
  • Water immersion optics designed for electrophysiological applications
  • Stability and reliability due to fixed stage concept

BX51WI

Fixed Stage Microscope
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Cameras

Not ApplicableShow Description
Not Applicable

Software

cellSensShow Description
cellSens

Providing intuitive operations and a seamless workflow, cellSens software’s user interface is customizable so you control the layout. Offered in a range of packages, cellSens software provides a variety of features optimized for your specific imaging needs. Its Graphic Experiment Manager and Well Navigator features facilitate 5D image acquisition. Achieve improved resolution through TruSight™ deconvolution and share your images using Conference Mode.

  • Improve experiment efficiency with TruAI™ deep-learning segmentation analysis, providing label-free nuclei detection and cell counting
  • Modular imaging software platform
  • Intuitive application-driven user interface
  • Broad feature set, ranging from simple snapshot to advanced multidimensional real-time experiments

cellSens

Imaging Software
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Not ApplicableShow Description
Not Applicable

Cell Culture Equipment

Not ApplicableShow Description
Not Applicable

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