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Previously only available in the U.S., Olympus is launching NoviSight 3D analysis software globally. For life science research that relies on cell analysis, the information provided by NoviSight software can improve the entire experiment process, from compound selection to animal experimentation and clinical trials in humans.

The Need for 3D Cell Analysis

The search for new drugs to treat diseases is a long, costly process. Biotechnology and pharmaceutical companies can invest up to 20 years and hundreds of millions of dollars in the effort to develop a new drug, yet the probability of success is low. As opposed to conventional 2D cell analysis, the use of 3D cell models that more accurately simulate a living body can help reduce these risks and speed up the experiment process. Using 3D cultured cell tissue, such as spheroids and organoids, researchers can analyze the effects and toxicity of new drugs in a bioenvironment similar to a living human body. This approach improves the accuracy of results at the preliminary stage of clinical trials.

Insightful Data, Intelligent Analysis

Olympus combined 3D imaging technology with powerful algorithms to create software capable of analyzing a whole cell model in three dimensions. Used with Olympus confocal laser scanning microscopes, such as the FLUOVIEW FV3000 system, NoviSight 3D cell analysis software provides images of the cell cluster down to the nuclei. The software’s True 3D technology uses multiple microplate images to provide accurate morphology data and the ability to quantitatively analyze the effect of medications, including growth suppression and cell survival rates. A range of parameters can be easily and precisely measured, enabling researchers to count the number of cells that have suppressed growth, proliferated or been annihilated. NoviSight 3D cell analysis software also makes it easy to compare the effects of different medications at various concentrations.

NoviSight software also has practical features that can facilitate and accelerate the interpretation and validation process. The results, including recognition, analysis and statistics, are displayed on a single screen. Users can view quantitative data as a scatterplot, heat map or graph, and clicking on a point in the graphical display automatically opens the corresponding image. It is easy to switch between 2D and 3D views of the sample, and data are easily exported as a CSV or FCS file for further analysis.

With the advancement of cell culture technology, working with 3D cell culture samples is increasingly common. NoviSight software’s powerful capabilities provide critical tools needed to analyze 3D cell cultures to potentially save researchers time and reduce costs.  

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