Introducing the FV4000

Introducing the FV4000 Laser Confocal Microscope

Transforming Precision Imaging

The metamorphosis is complete.

The next evolution of confocal imaging has arrived with the FLUOVIEW™ FV4000 microscope, and this time, we’re transforming how you think about confocal microscopy.

Powered by our pioneering new SilVIR™ detector, you can achieve results that you’ll need to see to believe. Don’t take it from us—see what your colleagues who’ve tried the system are saying.

"Compared to other confocals I have experience with yours was very stress-free to use (no fear of destroying the sample or feeling overwhelmed with the software/general operation) and required a minimal amount of adjustments from the user in order to produce good quality data without feeling that my options are limited.”

A headshot of Sanni Eramies from Tampere University

Sanni Erämies | Tampere University / Imaging Facility Tampere

“The detectors are easy to set up due to their high dynamic range. They can handle low signals, but also do not switch off and perform well with high signals. This makes it very user friendly to set up the microscope. The photon counting mode is a highly appreciated function. The high precision, simple adjustment, and high flexibility make the FV4000 a very valuable tool for imaging facilities with users of different experience levels and varying complexity in their imaging experiments.”

A headshot of Johannes Riemann from the University of Zurich.

Johannes Riemann | Center for Microscopy and Image Analysis, University of Zurich

Don’t take their word for it.

Experience the FV4000 microscope’s abilities for yourself, with innovations that include:

Game-changing dynamic range with high linearity for imaging from the macro scale to subcellular structures
Multiplexing of up to six channels simultaneously and up to 16 channels sequentially with TruSpectral technology
Redesigned high-speed, high-resolution, and larger field of view scanners for fixed and live cell imaging
Improved depth and photosensitivity with pioneering NIR capabilities and renowned optics

Peace of mind with the reliable, repeatable SilVIR detector
Industry-leading ten laser lines with a broader spectral range from 405 nm to 785 nm
Industry-leading detection range from 400–900nm
Live TruAI-based noise reduction with pre-trained deep learning algorithms
Modular design to meet researchers’ ever-changing needs, including the ability to upgrade to multiphoton imaging on a single system

Captured with a GaAsP-PMT detector (left) vs captured with the SilVIR detector (right)

The image captured using the SilVIR detector has extremely low background noise compared to the image captured using a GaAsP-PMT.

Captured with a GaAsP-PMT detector (left) vs captured with the SilVIR detector (right)

Instead of choosing to focus on either dim or bright fluorescence areas, the FV4000 microscope can capture both in one image without saturation or loss of information thanks to the SilVIR detector’s high dynamic range.

A confocal image of the tip of a Drosophila leg that has been stained with cyan, red, and blue fluorescent dyes.

Tip of a Drosophila leg (42-hour pupation), stained with phalloidin (AlexaFluor 405, F-actin, Cyan), anti-phosphotyrosine antibody (AlexaFluor 555, cell surface, red), and anti-HRP antibody (AlexaFluor 647, axon, blue). Sample Courtesy of: Zhengkuan Sun, Shigeo Hayashi, Laboratory for Morphogenetic Signaling, RIKEN Center for Biosystems Dynamics Research, Japan.

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Visit the FV4000 Webpage

“Together with the AI restoring tools, it gives a perfect combination for fast and high-quality volumetric imaging.”

Edwin Hernandez | Core Facility Manager, Cajal International Neuroscience Center (CINC)

“The new FV4000 will allow for faster imaging and better preservation of the sample and will allow better reproducibility.”

A headshot of Alexia Ferrand from the University of Basel.

Alexia Ferrand | Advanced Microscopy Specialist, University of Basel

Laser Confocal Microscope Timeline

“Demonstratively better signal to noise [than other systems].”

A headshot of Geoff Williams from Brown University.

Geoff Williams | Leduc Bioimaging Facility Manager, Brown University

“I am really impressed with the system and its performance. The super sensitivity was really impressive.”

Sara R. Roig | Advanced Microscopy Specialist, University of Basel

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